CSL Biotherapies, and its parent company, CSL Limited have reached an agreement with Merck & Co., Inc. on rights to market and distribute Afluria® in the United States under an exclusive, six-year agreement effective September 3, 2009. Merck has the exclusive right to sell and distribute Afluria® in the United States beginning with the 2010-2011 influenza season. The manufacture, filling and packaging of Afluria® will continue and will not change with this agreement; CSL Ltd. will retain the Afluria® license.

For information on prebooking Afluria® for the 2010-2011 season, please visit www.merckvaccines.com/afluria or call the Merck Vaccine Customer Center at 877-829-6372.

For any questions relating to Afluria® 2009-2010, please contact 1-888-435-8633 or CustomerSupport@cslbiotherapies.com.

Afluria® 2009-2010 Prescribing Information (Revised 11/2009)

CSL Biotherapies' plans or capacity for manufacturing and delivering its pandemic Influenza A (H1N1) Monovalent Vaccine to US Human Health Services (HHS) are not affected by the seasonal influenza vaccine agreement. For any questions relating to CSL Biotherapies' Influenza A (H1N1) 2009 Monovalent Vaccine, please contact 1-888-435-8633 or CustomerSupport@cslbiotherapies.com.

CSL Biotherapies' Influenza A (H1N1) 2009 Monovalent Vaccine Prescribing Information

Afluria
 

About Afluria®

Afluria® is an influenza vaccine that is available in thimerosal-free, prefilled syringes and multi-use vials containing thimerosal as a preservative. Afluria® was approved just in time for the 2008-2009 flu season.

Afluria® is distributed in the United States by CSL Biotherapies, the vaccine company of CSL Limited, and one of the few providers of flu vaccines in the world today. With 40 years of influenza vaccine manufacturing and distribution experience, CSL Limited has developed extensive expertise and plays a central role in helping to reduce the risk of flu epidemics in many countries. Being a reliable influenza vaccine supplier comes from not only our extensive expertise and knowledge, but also our relentless dedication to the patients we serve.

Afluria® Influenza Virus Vaccine is a sterile suspension prepared from influenza virus, which is propagated in the allantoic fluid of embryonic chicken eggs. Following harvest, the virus is purified in a sucrose density gradient using a continous flow zonal centrifuge. The purified virus is inactivated with beta propiolactone, and the virus particles are disrupted using sodium taurdeoxycholate to produce a "split virion." The disrupted virus is further purified and suspended in a phosphate-buffered isotonic solution.

A purified, inactivated, split virion influenza vaccine, the vaccine is made by “splitting” the purified, inactivated, whole virus to form fragments. This process reduces the number of adverse events experienced with whole virus vaccines, yet leaves the surface antigens and structural proteins in their original antigenic form.

Why choose Afluria®?
  • Thimerosal-free (mercury-free) in a convenient latex-free prefilled syringe (without needle), or
  • Multi-dose vial containing thimerosal as a preservative and latex-free formulation
  • Indicated for adults 18 years and older
  • Reliable availability throughout the flu season
  • Trusted influenza vaccine manufacturer with 40 years experience

Afluria®—For the 2008–2009 Season

Afluria® is standardized according to United States Public Health Service (USPHS) requirement for the 2008-2009 influenza season and contains no less than 15 mcg hemagglutinin per dose for each of the 3 influenza strains recommended for the 2008-2009 US winter influenza season. The strains for this season include the following1:

  • A/Brisbane/59/2007 (H1N1)1
  • A/Uruguay/716/2007 (H3N2) (A/Brisbane/10/2007-like virus)1
  • B/Florida/4/2006-like virus1

REFERENCES:

  1. Fiore AE, Shay DK, Haber P, et al. Prevention and control of influenza: recommendations of the Advisory Committee on Immunization Practices. MMWR. 2008;57.
 

Immunogenicity

Learn more about the Afluria® immune response.
Go Now >

Safety

View Safety Data from Afluria® clinical studies.
Go Now >

Product Presentations

Afluria® – Available in 2 convenient formulations.
Go Now >
 

Order Afluria Now

Share with a Colleague